Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia

CL Whitehead; SP Walker; M Lappas; S Tong

Journal article

Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia

CL Whitehead, SP Walker, M Lappas, S Tong

Journal of Perinatology | NATURE PUBLISHING GROUP | Published : 2013

DOI: 10.1038/jp.2013.16

Abstract

Objective:To determine whether the intrinsic apoptosis pathway is differentially expressed in placenta and maternal blood in severe preterm fetal growth restriction (FGR) and pre-eclampsia (PE), and to examine whether circulating RNA in maternal blood may be potential biomarkers.Study design:Maternal blood samples and placental biopsies were collected from women with preterm: FGR (n=20), PE without FGR (n=8) and controls (n=20). Real-time PCR examined the expression of genes in the intrinsic apoptosis pathway in FGR and PE, stratified according to the severity of placental insufficiency.Result: Severe preterm FGR, with or without PE, was associated with increased expression of BCL2, BCL-XL, ..

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University of Melbourne Researchers

Clare Whitehead Author

Susan Walker Author

Martha Lappas Author

Stephen Tong Author

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Grants

Awarded by Royal Perth Hospital Medical Research Foundation

Funding Acknowledgements

We are grateful for funding from the Royal Australian and New Zealand College of Obstetricians and Gynecologists Arthur Wilson Scholarship, a William Buckland Foundation Grant, a Medical Research Foundation For Women and Babies Grant and a NHMRC Project Grant (no.1028521). ML and ST are supported by NHMRC Career Development Fellowships (MLno.454777) (STno.490870). We thank Gillian Barker for her assistance in sample processing. This project was funded by a Royal Australian and New Zealand College of Obstetricians and Gynecologists Arthur Wilson Scholarship, a William Buckland Foundation Grant, a Medical Research Foundation For Women and Babies Grant and a NHMRC Project Grant (no.1028521). ML and ST are supported by NHMRC Career Development Fellowships (STno.490970)